The relation of thermodynamics with the metabolism of the cell

The relation of thermodynamics with the metabolism of the cell(I suck at explaining things)

There are two sets of reactions that constitute the metabolism of the cell: anabolism and catabolism. Those reactions are promoted by enzymes. To what kind of reaction do they pertain? And how?

According to the second law of thermodynamics, in the universe or in any isolated system, the degree of disorder can only increase. We can express this statement in terms of probability by saying that systems will change spontaneously toward those arrangements that have the greatest probability. For example, consider a box of 100 coins all lying heads up. If you keep jiggling the box, the ratio of heads to tails changes toward 50 to 50 because of the probability.

We can explain how enzyme related biochemical reactions are performed by the second law of thermodynamics. Basically, while energetically favourable reactions spontaneously proceed until they reach a state of equilibrium(because the degree of disorder increases), enzyme related reactions are energetically unfavourable, and thus cannot take place by itself. Then, how do they occur? We can measure the amount of disorder by the free energy change, denoted ΔG. Free energy is needed to increase disorder. Thus, when ΔG is negative, it is easy for energetically favourable reactions to occur, and when ΔG is positive, energetically unfavourable reactions are promoted. Enzyme related reactions take place when they are coupled to a second reaction with a negative ΔG large enough that the net ΔG of the entire process is negative.